The Demarcated Region of Vinho Verde is located in the northwest of Portugal in an area traditionally known as Entre-Douro-e-Minho. Its limits are the Minho River in the North (border with Galicia), the mountainous areas in the East and South, forming the natural border between the Atlantic Entre-Douro-e-Minho and the Mediterranean inland regions, and the Atlantic Ocean as its western limit.

Orografically the region presents itself as "a wide amphitheater rising gradually from the maritime border to the inland " (Amorim Girão), exposed to the Atlantic Ocean influence, being this even more reinforced by the main river valleys orientation, that facilitates the maritime winds' penetration.